EVALUATING A MARKERLESS METHOD FOR STUDYING ARTICULATORY MOVEMENTS: APPLICATION TO A SYLLABLE REPETITION TASK

none4siThe analysis of the articulatory movements allows investigating the kinematic characteristics of some speech disorders. However, the methodologies most used until now, as electromagnetic articulography and optoelectronic systems, are expensive and intrusive which limit their use to specialized laboratories. In this work, we use a completely markerless and low-cost technique to study lip movements during a syllable repetition task. By means of a Kinect-like and an existing face tracking algorithm, we are able to track the movements of the lower lip, testing the performances against a reference method (marker-based optoelectronic system). Good results were obtained in terms of RMSE for the tracking of the lower lip during the repetitions. Some kinematic measures, as opening and closing velocities and accelerations, were also computed. Despite the limitations in terms of image resolution, these results are very promising in the optic of developing a new markerless system for studying speech articulation.noneBandini A.; Ouni S.; Orlandi S.; Manfredi C.Bandini A.; Ouni S.; Orlandi S.; Manfredi C

Maladie De Forestier Revelee Par Une Dysphagie A Propos De Deux Cas

La maladie de Forestier ou hyperostose ankylosante vertébrale engainante est un désordre musculo-squelettique non inflammatoire responsable d\'une ossification ligamentaire essentiellement du ligament longitudinal antérieur. Elle touche de préférence l\'homme de plus de 50 ans. La dysphagie est un symptôme rarement observé dans l\'évolution de la maladie de Forestier. Nous rapportons deux cas révélés par une dysphagie isolée. Il s\'agit de deux hommes âgés de 50 et 56 ans. Le diagnostic était radiologique. La radiographie standard du rachis a objectivé des ostéophytes du rachis cervical. Le transit oesogastroduodénal a montré une compression modérée de l\'oesophage cervical. Le traitement était médical reposant sur les anti inflammatoires non stéroïdiens et les antalgiques. Le traitement chirurgical est indiqué dans les cas de dysphagie sévère. Keywords: maladie de Forestier, hyperostose vertébrale, dysphagie. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 18 2007: pp. 55-5

Tongue control and its implication in pronunciation training

International audiencePronunciation training based on speech production techniques illustrating tongue movements is gaining popularity. However, there is not sufficient evidence that learners can imitate some tongue animation. In this paper, we argue that although controlling tongue movement related to speech is not such an easy task, training with visual feedback improves its control. We investigated human awareness of controlling their tongue body gestures. In a first experiment, participants were asked to perform some tongue movements composed of two sets of gestures. This task was evaluated by observing ultrasound imaging of the tongue recorded during the experiment. No feedback was provided. In a second experiment, a short session of training was added where participants can observe ultrasound imaging in real time of their own tongue movements. The goal was to increase their awareness of their tongue gestures. A pretest and posttest were carried out without any feedback. The results suggest that without a priori knowledge, it is not easy to finely control tongue body gestures. The second experiment showed that we gained in performance after a short training session and this suggests that providing visual feedback, even a short one, improves tongue gesture awareness

Study of Leishmania pathogenesis in mice : experimental considerations

Although leishmaniases are endemic in 98 countries, they are still considered neglected tropical diseases. Leishmaniases are characterized by the emergence of new virulent and asymptomatic strains of Leishmania spp. and, as a consequence, by a very diverse clinical spectrum. To fight more efficiently these parasites, the mechanisms of host defense and of parasite virulence need to be thoroughly investigated. To this aim, animal models are widely used. However, the results obtained with these models are influenced by several experimental parameters, such as the mouse genetic background, parasite genotype, inoculation route/infection site, parasite dose and phlebotome saliva. In this review, we propose an update on their influence in the two main clinical forms of the disease: cutaneous and visceral leishmaniases

Deploying Search Based Software Engineering with Sapienz at Facebook

We describe the deployment of the Sapienz Search Based Software Engineering (SBSE) testing system. Sapienz has been deployed in production at Facebook since September 2017 to design test cases, localise and triage crashes to developers and to monitor their fixes. Since then, running in fully continuous integration within Facebook’s production development process, Sapienz has been testing Facebook’s Android app, which consists of millions of lines of code and is used daily by hundreds of millions of people around the globe. We continue to build on the Sapienz infrastructure, extending it to provide other software engineering services, applying it to other apps and platforms, and hope this will yield further industrial interest in and uptake of SBSE (and hybridisations of SBSE) as a result

In Vitro Evaluation of a Soluble Leishmania Promastigote Surface Antigen as a Potential Vaccine Candidate against Human Leishmaniasis

International audiencePSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in severalLeishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in vaccinated mice.We evaluated humoral and cellular immune responses induced by a L. amazonensis PSA protein (LaPSA-38S) produced in aL. tarentolae expression system. This was done in individuals cured of cutaneous leishmaniasis due to L. major (CCLm) or L.braziliensis (CCLb) or visceral leishmaniasis due to L. donovani (CVLd) and in healthy individuals. Healthy individuals weresubdivided into immune (HHR-Lm and HHR-Li: Healthy High Responders living in an endemic area for L. major or L. infantuminfection) or non immune/naive individuals (HLR: Healthy Low Responders), depending on whether they produce high orlow levels of IFN-c in response to Leishmania soluble antigen. Low levels of total IgG antibodies to LaPSA-38S were detectedin sera from the studied groups. Interestingly, LaPSA-38S induced specific and significant levels of IFN-c, granzyme B and IL-10 in CCLm, HHR-Lm and HHR-Li groups, with HHR-Li group producing TNF-a in more. No significant cytokine response wasobserved in individuals immune to L. braziliensis or L. donovani infection. Phenotypic analysis showed a significant increasein CD4+ T cells producing IFN-c after LaPSA-38S stimulation, in CCLm. A high positive correlation was observed between thepercentage of IFN-c-producing CD4+ T cells and the released IFN-c. We showed that the LaPSA-38S protein was able toinduce a mixed Th1 and Th2/Treg cytokine response in individuals with immunity to L. major or L. infantum infectionindicating that it may be exploited as a vaccine candidate. We also showed, to our knowledge for the first time, the capacityof Leishmania PSA protein to induce granzyme B production in humans with immunity to L. major and L. infantum infectio

Monkeys and Humans Share a Common Computation for Face/Voice Integration

Speech production involves the movement of the mouth and other regions of the face resulting in visual motion cues. These visual cues enhance intelligibility and detection of auditory speech. As such, face-to-face speech is fundamentally a multisensory phenomenon. If speech is fundamentally multisensory, it should be reflected in the evolution of vocal communication: similar behavioral effects should be observed in other primates. Old World monkeys share with humans vocal production biomechanics and communicate face-to-face with vocalizations. It is unknown, however, if they, too, combine faces and voices to enhance their perception of vocalizations. We show that they do: monkeys combine faces and voices in noisy environments to enhance their detection of vocalizations. Their behavior parallels that of humans performing an identical task. We explored what common computational mechanism(s) could explain the pattern of results we observed across species. Standard explanations or models such as the principle of inverse effectiveness and a “race” model failed to account for their behavior patterns. Conversely, a “superposition model”, positing the linear summation of activity patterns in response to visual and auditory components of vocalizations, served as a straightforward but powerful explanatory mechanism for the observed behaviors in both species. As such, it represents a putative homologous mechanism for integrating faces and voices across primates

Application of an electronic tongue for Tunisian olive oils' classification according to olive cultivar or physicochemical parameters

Olive oil commercialization has a great impact on the economy of several countries, namely Tunisia, being prone to frauds. Therefore, it is important to establish analytical techniques to ensure labeling correctness concerning olive oil quality and olive cultivar. Traditional analytical techniques are quite expensive, time consuming and hardly applied in situ, considering the harsh environments of the olive industry. In this work, the feasibility of applying a potentiometric electronic tongue with cross-sensitivity lipid membranes to discriminate Tunisian olive oils according to their quality level (i.e., extra virgin, virgin or lampante olive oils) or autochthonous olive cultivar (i.e., cv Chétoui and cv Shali) was evaluated for the first time. Linear discrimination analysis coupled with the simulated annealing variable selection algorithm showed that the signal profiles of olive oils hydroethanolic extracts allowed olive oils discrimination according to physicochemical quality level (classification model based on 25 signals enabling 84 ± 9% correct classifications for repeated K-fold cross-validation), and olive cultivar (classification model based on 20 signals with an average sensitivity of 94 ± 6% for repeated K-fold cross-validation), regardless of the geographical origin and olive variety or the olive quality, respectively. The results confirmed, for the first time, the potential discrimination of the electronic tongue, attributed to the observed quantitative response (sensitivities ranging from 66.6 to +57.7 mV/decade) of the E-tongue multi-sensors towards standard solutions of polar compounds (aldehydes, esters and alcohols) usually found in olive oils and that are related to their sensory positive attributes like green and fruity.This work was financially supported by Project POCI-01–0145-FEDER-006984–Associate Laboratory LSRE-LCM and by Project UID/QUI/00616/2013–CQ-VR both funded by FEDER—Fundo Europeu de Desenvolvimento Regional through COMPETE2020-Programa Operacional Competitividade e Internacionalização (POCI)—and by national funds through FCTFundação para a Ciência e a Tecnologia, Portugal. Strategic funding of UID/BIO/04469/2013 unit is also acknowledged. Nuno Rodrigues thanks FCT, POPH-QREN and FSE for the Ph.D. Grant (SFRH/ BD/104038/2014).info:eu-repo/semantics/publishedVersio